http://test.repositoriodigital.com:8080/handle/123456789/95922 2026-10-29T01:34:22Z http://test.repositoriodigital.com:8080/handle/123456789/194515 Patrimonio y territorios inteligentes - Sector doce de octubre - Estrategias de intervención para el siglo XXI; Heritage and smart territories El trabajo de investigación gira en torno a un sector tradicional de Bogotá, conocido como el Doce de Octubre, ubicado en la localidad de Barrios Unidos (UPZ 22) al noroccidente de la ciudad de Bogotá. Es un sector consolidado, reconocido por la gastronomía popular, la industria manufacturera del mueble y el trabajo de la madera. En sus barrios se logra percibir el espíritu del lugar, que da cuenta de la memoria histórica del sector. Vinculado a personajes importantes como Jorge Eliecer Gaitán que sin duda marca el punto de partida de la construcción de la identidad obrera capitalina. El Doce de Octubre tiene una oferta comercial que da cuenta de un valor funcional ya que relaciona aspectos que tienen que ver con la función del recurso cultural con las dinámicas productivas y sociales. Es por ello que el enfoque de trabajo de investigación gira en torno a la búsqueda de la relación entre la arquitectura, las plataformas digitales y la productividad del lugar, siendo la plaza de mercado el principal catalizador, entendido como el acelerador de la dinámica urbana y principal plataforma de difusión patrimonial.; The research work turns around a traditional sector of Bogotá, known as " Doce de Octubre", located in Barrios Unidos (UPZ 22) in the northwest of the city of Bogotá. Its a consolidated sector, recognized because its popular gastronomy, the manufacturing industry of furniture of wood. In their neighbourhoods you can perceive the spirit of the place, which gives an account of the historical memory of the sector. Linked to important figures such as Jorge Eliecer Gaitán that undoubtedly marks the starting point of the construction of the workers' identity in Bogotá. This area has a commercial offer that gives an account of a functional value since it relates aspects that have to do with the function of the cultural resource with the productive and social dynamics. Thats why the purpose of the investigation turns arround the search for the relationship between architecture, digital platforms and the productivity of the place, with the market place being the main catalyst, understood as the accelerator of the urban dynamics and main platform of patrimonial diffusion.; Arquitecto (a); Pregrado http://test.repositoriodigital.com:8080/handle/123456789/194513 La libertad de expresión en tiempos de redes sociales : estudio desde la jurisprudencia constitucional colombiana; Freedom of speech in the age of social networks : study from the colombian constitutional jurisprudence La masificación del uso de las redes sociales en Colombia, ha impactado distintas esferas, particularmente en el aspecto jurídico. Esta investigación aborda la tensión que esto ha generado entre el derecho a la libertad de expresión en redes sociales y la honra y el buen nombre. Pues, esto ha generado que los jueces constitucionales se enfrenten a retos que han demandado el desarrollo de criterios para solucionar la tensión de los de derechos fundamentales en cuestión, sin desconocer principios democráticos. Esta monografía explica el contexto de la tensión y explora la idoneidad de las soluciones que ha desarrollado la jurisprudencia.; The massive use of social networks in Colombia has impacted different spheres, particularly in the legal aspect. This research addresses the tension between freedom of speech in social networks and other constitutional rights such as honor and good name, which has led constitutional judges to face challenges that have required the development of certain criteria to solve the tension of the fundamental rights in question, without ignoring democratic principles. This study explains the context of the issue and explores the appropriateness of the solutions that jurisprudence has developed.; Abogado (a); Pregrado http://test.repositoriodigital.com:8080/handle/123456789/194514 Genotyping low-grade gliomas among hispanics Q2; 164-172; Background. Low-grade gliomas (LGGs) are classified by the World Health Organization as astrocytoma (DA), oligodendroglioma (OD), and mixed oligoastrocytoma (OA). TP53 mutation and 1p19q codeletion are the most-commonly documented molecular abnormalities. Isocitrate dehydrogenase (IDH) 1/2 mutations are frequent in LGGs; however, IDH-negative gliomas can also occur. Recent research suggests that ATRX plays a significant role in gliomagenesis. Methods. We investigated p53 and Olig2 protein expression, and MGMT promoter methylation, 1p19q codeletion, IDH, and ATRX status in 63 Colombian patients with LGG. The overall survival (OS) rate was estimated and compared according to genotype. Results. The most common histology was DA, followed by OD and OA. IDH1/2 mutations were found in 57.1% and MGMT+ (positive status of MGMT promoter methylation methyl-guanyl-methyl-transferase gene) in 65.1% of patients, while overexpression of p53 and Olig2 was present in 30.2% and 44.4%, respectively, and 1p19q codeletion in 34.9% of the patients. Overexpression of ATRX was analyzed in 25 patients, 16% tested positive and were also mutations in isocitrate dehydrogenase and negative 1p19q-codelition. The median follow-up was 15.8 months (95% CI, 7.6–42.0) and OS was 39.2 months (95% CI, 1.3–114). OS was positively and significantly affected by MGMT+, 1p19q codeletion, surgical intervention extent, and number of lobes involved. Multivariate analysis confirmed that MGMT methylation status and 1p19q codeletion affected OS. Conclusions. This is the first study evaluating the molecular profile of Hispanic LGG patients. Findings confirmed the prognostic relevance of MGMT methylation and 1p19q codeletion, but do not support IDH1/2 mutation as a relevant marker. The latter may be explained by sample size and selection bias. ATRX alterations were limited to patients with DA and were mutations in isocitrate dehydrogenase and negative 1p19q-codelition. http://test.repositoriodigital.com:8080/handle/123456789/194509 Serenade : Un montaje interdisciplinar basado en la Serenata para tenor, corno y orquesta de cuerdas Op.31 de Benjamin Britten; Serenade : An interdisciplinary performance based on Serenade for tenor, horn and string orchestra Op.31 by Benjamin Britten Serenade: Un montaje interdisciplinar basado en la Serenata para tenor, corno y orquesta de cuerdas Op.31 de Benjamin Britten, es un texto de carácter creativo que reúne un análisis musical de la Serenata para tenor, corno y orquesta de cuerdas Op.31 con el fin de plantear una nueva forma de presentar la obra al público desde un diseño interdisciplinar con las artes visuales, escénicas y por supuesto las musicales. Con este diseño interdisciplinar se pretende impulsar a nuevos artistas a traducir obras académicas existentes al ojo del nuevo espectador del Siglo XXI.; Serenade: An interdisciplinary performance based on Serenade for tenor, horn and string orchestra Op.31 by Benjamin Britten, is a creative text that brings together a musical analysis of the Serenade for tenor, horn and string orchestra Op.31 with the purpose of presenting a new way to show this music to the public from an interdisciplinary design with the visual, performing arts and of course the musical arts. With this interdisciplinary design, it is intended to encourage new artists to translate existing academic works into the eye of the new 21st century viewer.; Maestro (a) en Música; Pregrado