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CO, Pb++ and SO2 effects on L-type calcium channel and action potential in human atrial myocytes. In silico study

Efectos del CO, Pb++, y SO2 en el canal de calcio tipo L y potencial de acción en miocitos auriculares humanos. Estudio en silico

dc.creatorPachajoa, Diana C.
dc.creatorTobón, Catalina
dc.creatorUgarte, Juan P.
dc.creatorSaiz, Javier
dc.date2017-09-04
dc.date.accessioned2021-03-18T21:06:51Z
dc.date.available2021-03-18T21:06:51Z
dc.identifierhttps://revistas.itm.edu.co/index.php/tecnologicas/article/view/718
dc.identifier10.22430/22565337.718
dc.identifier.urihttp://test.repositoriodigital.com:8080/handle/123456789/11711
dc.descriptionExposure to air pollutants like carbon monoxide (CO), lead (Pb++) and sulfur dioxide (SO2) promotes the occurrence of cardiovascular diseases. Experimental studies have shown that CO, Pb++ and SO2 block L-type calcium channels, reducing the calcium current (ICaL) and the action potential duration (APD), which favors the initiation of atrial arrhythmias. The goal is to study the effects of CO, Pb++ and SO2 at different concentrations on ICaL and action potential using computational simulation. For this purpose, models of the effects of the air pollutants on the atrial L-type calcium channel were developed and were incorporated into a mathematical model of a human atrial cell. The results suggest that CO, Pb++ and SO2 block the ICaL current in a fraction that increases along with the concentration, generating an APD shortening. These results are consistent with experimental studies. The combined effect of the three air pollutants produced an APD shortening, which is considered to be a pro-arrhythmic effect.en-US
dc.descriptionLa exposición a contaminantes atmosféricos, como el monóxido de carbono (CO), plomo (Pb++) y dióxido de azufre (SO2), promueve la aparición de enfermedades cardiovasculares. Estudios experimentales han demostrado que el CO, el Pb++ y el SO2 bloquean los canales de calcio tipo L, disminuyendo la corriente de calcio (ICaL) y la duración del potencial de acción (APD), favoreciendo el inicio de arritmias auriculares. El objetivo es estudiar los efectos del CO, Pb++ y SO2 a diferentes concentraciones, sobre ICaL y el potencial de acción auricular mediante simulación computacional. Para ello, se desarrollaron modelos matemáticos de los efectos de los contaminantes atmosféricos sobre el canal de calcio auricular tipo L y se incorporaron en un modelo matemático de células auriculares humanas. Los resultados sugieren que el CO, el Pb++ y el SO2, bloquean la corriente ICaL en una fracción que aumenta a medida que aumenta, la concentración, generando un acortamiento del APD. Estos resultados son consistentes con estudios experimentales. El efecto combinado de los tres contaminantes atmosféricos generó un acortamiento del APD, lo cual es considerado un efecto pro-arrítmico.es-ES
dc.formatapplication/pdf
dc.languageeng
dc.publisherInstituto Tecnológico Metropolitano (ITM)en-US
dc.relationhttps://revistas.itm.edu.co/index.php/tecnologicas/article/view/718/695
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dc.rightsCopyright (c) 2017 https://creativecommons.org/licenses/by/3.0/deed.es_ESen-US
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/4.0en-US
dc.sourceTecnoLógicas; Vol. 20 No. 40 (2017); 113-123en-US
dc.sourceTecnoLógicas; Vol. 20 Núm. 40 (2017); 113-123es-ES
dc.source2256-5337
dc.source0123-7799
dc.subjectAir pollutionen-US
dc.subjectatrial action potentialen-US
dc.subjectcalcium channelen-US
dc.subjectin silico modelsen-US
dc.subjectContaminantes atmosféricoses-ES
dc.subjectpotencial de acción auriculares-ES
dc.subjectcanal de calcioes-ES
dc.subjectmodelos en silicoes-ES
dc.titleCO, Pb++ and SO2 effects on L-type calcium channel and action potential in human atrial myocytes. In silico studyen-US
dc.titleEfectos del CO, Pb++, y SO2 en el canal de calcio tipo L y potencial de acción en miocitos auriculares humanos. Estudio en silicoes-ES
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typeResearch Papersen-US
dc.typeArtículos de investigaciónes-ES


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