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Lung Cancer Gene Regulatory Network of Transcription Factors Related to the Hallmarks of Cancer

dc.contributorPontificia Universidad Javeriana. Facultad de Medicina. Instituto de Genética Humana. Grupo de investigación Instituto de Genética Humana
dc.contributorRojas, Adriana
dc.creatorOtálora-Otálora, Beatriz Andrea
dc.creatorLópez-Kleine, Liliana
dc.creatorRojas, Adriana
dc.date2023-08-28T16:16:30Z
dc.date2023-08-28T16:16:30Z
dc.date2023-01-05
dc.date.accessioned2025-10-30T13:07:52Z
dc.date.available2025-10-30T13:07:52Z
dc.identifierhttps://www.mdpi.com/1467-3045/45/1/29
dc.identifier1467-3037 / 1467-3045 (Electrónico)
dc.identifierhttp://hdl.handle.net/10554/65327
dc.identifierhttps://doi.org/10.3390/cimb45010029
dc.identifierinstname:Pontificia Universidad Javeriana
dc.identifierreponame:Repositorio Institucional - Pontificia Universidad Javeriana
dc.identifierrepourl:https://repository.javeriana.edu.co
dc.identifier.urihttp://test.repositoriodigital.com:8080/handle/123456789/175715
dc.descriptionQ3
dc.descriptionQ2
dc.descriptionPacientes con Cáncer de pulmón
dc.descriptionThe transcriptomic analysis of microarray and RNA-Seq datasets followed our own bioinformatic pipeline to identify a transcriptional regulatory network of lung cancer. Twenty-six transcription factors are dysregulated and co-expressed in most of the lung cancer and pulmonary arterial hypertension datasets, which makes them the most frequently dysregulated transcription factors. Co-expression, gene regulatory, coregulatory, and transcriptional regulatory networks, along with fibration symmetries, were constructed to identify common connection patterns, alignments, main regulators, and target genes in order to analyze transcription factor complex formation, as well as its synchronized co-expression patterns in every type of lung cancer. The regulatory function of the most frequently dysregulated transcription factors over lung cancer deregulated genes was validated with ChEA3 enrichment analysis. A Kaplan–Meier plotter analysis linked the dysregulation of the top transcription factors with lung cancer patients’ survival. Our results indicate that lung cancer has unique and common deregulated genes and transcription factors with pulmonary arterial hypertension, co-expressed and regulated in a coordinated and cooperative manner by the transcriptional regulatory network that might be associated with critical biological processes and signaling pathways related to the acquisition of the hallmarks of cancer, making them potentially relevant tumor biomarkers for lung cancer early diagnosis and targets for the development of personalized therapies against lung cancer.
dc.descriptionhttps://orcid.org/0000-0001-8528-4433
dc.descriptionRevista Internacional - Indexada
dc.descriptionA2
dc.descriptionNo
dc.formatPDF
dc.formatapplication/pdf
dc.formatapplication/pdf
dc.languageeng
dc.relation434
dc.relation464
dc.relationCurrent Issues in Molecular Biology
dc.relation45
dc.relation1
dc.rightsAtribución-NoComercial 4.0 Internacional
dc.rightshttp://creativecommons.org/licenses/by-nc/4.0/
dc.rightshttp://purl.org/coar/access_right/c_abf2
dc.subjectLung cancer
dc.subjectPulmonary arterial hypertension
dc.subjectDifferentially expressed genes
dc.subjectTranscription factors
dc.subjectCo-expression networks
dc.subjectCommon connection patterns
dc.subjectGene regulatory network
dc.subjectCoregulatory network
dc.subjectFibration symmetries
dc.subjectTranscriptional regulatory network
dc.subjectLung cancer biomarkers
dc.subjectPatient’s survival
dc.subjectTranscriptomics and bioinformatics
dc.titleLung Cancer Gene Regulatory Network of Transcription Factors Related to the Hallmarks of Cancer
dc.typehttp://purl.org/coar/version/c_ab4af688f83e57aa
dc.typeArtículo de revista
dc.typehttp://purl.org/coar/resource_type/c_6501


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