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2q36.3 is associated with prognosis for oestrogen receptor-negative breast cancer patients treated with chemotherapy

dc.contributorPontificia Universidad Javeriana. Facultad de Medicina. Instituto de Genética Humana
dc.creatorLi, Jingmei
dc.creatorLindström, Linda S.
dc.creatorFoo, Jia N.
dc.creatorRafiq, Sajjad
dc.creatorSchmidt, Marjanka K.
dc.creatorPharoah, Paul D. P.
dc.creatorMichailidou, Kyriaki
dc.creatorDennis, Joe
dc.creatorBolla, Manjeet K.
dc.creatorWang, Qin
dc.creatorVan‘t Veer, Laura J.
dc.creatorCornelissen, Sten
dc.creatorRutgers, Emiel
dc.creatorSouthey, Melissa C.
dc.creatorApicella, Carmel
dc.creatorDite, Gillian S.
dc.creatorHopper, John L.
dc.creatorFasching, Peter A.
dc.creatorHaeberle, Lothar
dc.creatorEkici, Arif B.
dc.creatorBeckmann, Matthias W.
dc.creatorBlomqvist, Carl
dc.creatorMuranen, Taru A.
dc.creatorAittomäki, Kristiina
dc.creatorLindblom, Annika
dc.creatorMargolin, Sara
dc.creatorMannermaa, Arto
dc.creatorKosma, Veli-Matti
dc.creatorHartikainen, Jaana M.
dc.creatorKataja, Vesa
dc.creatorChenevix-Trench, Georgia
dc.creatorkConFab Investigators
dc.creatorPhillips, Kelly-Anne
dc.creatorMcLachlan, Sue-Anne
dc.creatorLambrechts, Diether
dc.creatorThienpont, Bernard
dc.creatorSmeets, Ann
dc.creatorWildiers, Hans
dc.creatorChang-Claude, Jenny
dc.creatorFlesch-Janys, Dieter
dc.creatorSeibold, Petra
dc.creatorRudolph, Anja
dc.creatorGiles, Graham G.
dc.creatorBaglietto, Laura
dc.creatorSeveri, Gianluca
dc.creatorHaiman, Christopher A.
dc.creatorHenderson, Brian E.
dc.creatorSchumacher, Fredrick
dc.creatorMarchand, Loic Le
dc.creatorKristensen, Vessela
dc.creatorGrenaker Alnæs, Grethe I.
dc.creatorBorresen-Dale, Anne-Lise
dc.creatorNord, Silje
dc.creatorWinqvist, Robert
dc.creatorPylkäs, Katri
dc.creatorJukkola-Vuorinen, Arja
dc.creatorGrip, Mervi
dc.creatorAndrulis, Irene L.
dc.creatorKnight, Julia A.
dc.creatorGlendon, Gord
dc.creatorTchatchou, Sandrine
dc.creatorDevilee, Peter
dc.creatorTollenaar, Robert
dc.creatorSeynaeve, Caroline
dc.creatorHooning, Maartje
dc.creatorKriege, Mieke
dc.creatorHollestelle, Antoinette
dc.creatorVan Den Ouweland, Ans
dc.creatorLi, Yi
dc.creatorHamann, Ute
dc.creatorTorres, Diana
dc.creatorUlmer, Hans U.
dc.creatorRüdiger, Thomas
dc.creatorShen, Chen-Yang
dc.creatorHsiung, Chia-Ni
dc.creatorWu, Pei-Ei
dc.creatorChen, Shou-Tung
dc.creatorTeo, Soo Hwang
dc.creatorMohd Taib, Nur Aishah
dc.creatorYip, Cheng Har
dc.creatorHo, Gwo Fuang
dc.creatorMatsuo, Keitaro
dc.creatorIto, Hidemi
dc.creatorIwata, Hiroji
dc.creatorTajima, Kazuo
dc.creatorKang, Daehee
dc.creatorChoi, Ji-Yeob
dc.creatorPark, Sue K.
dc.creatorYoo, Keun-Young
dc.creatorMaishman, Tom
dc.creatorTapper, William J.
dc.creatorDunning, Alison
dc.creatorShah, Mitul
dc.creatorLuben, Robert
dc.creatorBrown, Judith
dc.creatorKhor, Chiea Chuen
dc.creatorEccles, Diana M.
dc.creatorNevanlinna, Heli
dc.creatorEaston, Douglas
dc.creatorHumphreys, Keith
dc.creatorLiu, Jianjun
dc.creatorHall, Per
dc.creatorCzene, Kamila
dc.date2020-03-09T18:51:49Z
dc.date2020-04-15T13:36:36Z
dc.date2020-03-09T18:51:49Z
dc.date2020-04-15T13:36:36Z
dc.date2014-06-17
dc.date.accessioned2025-10-30T14:01:25Z
dc.date.available2025-10-30T14:01:25Z
dc.identifierhttps://www.nature.com/articles/ncomms5051#article-info
dc.identifier2041-1723 (Electrónico)
dc.identifierhttp://hdl.handle.net/10554/47547
dc.identifierhttps://doi.org/10.1038/ncomms5051
dc.identifier.urihttp://test.repositoriodigital.com:8080/handle/123456789/192520
dc.descriptionQ1
dc.descriptionQ1
dc.descriptionArtículo original
dc.description1-9
dc.descriptionLarge population-based registry studies have shown that breast cancer prognosis is inherited. Here we analyse single-nucleotide polymorphisms (SNPs) of genes implicated in human immunology and inflammation as candidates for prognostic markers of breast cancer survival involving 1,804 oestrogen receptor (ER)-negative patients treated with chemotherapy (279 events) from 14 European studies in a prior large-scale genotyping experiment, which is part of the Collaborative Oncological Gene-environment Study (COGS) initiative. We carry out replication using Asian COGS samples (n=522, 53 events) and the Prospective Study of Outcomes in Sporadic versus Hereditary breast cancer (POSH) study (n=315, 108 events). Rs4458204_A near CCL20 (2q36.3) is found to be associated with breast cancer-specific death at a genome-wide significant level (n=2,641, 440 events, combined allelic hazard ratio (HR)=1.81 (1.49–2.19); P for trend=1.90 × 10−9). Such survival-associated variants can represent ideal targets for tailored therapeutics, and may also enhance our current prognostic prediction capabilities.
dc.formatPDF
dc.formatapplication/pdf
dc.formatPapel / Electrónico
dc.formatapplication/pdf
dc.languagespa
dc.rightsAtribución-NoComercial 4.0 Internacional
dc.rightshttp://creativecommons.org/licenses/by-nc/4.0/
dc.sourceNature Communications; Vol. 5 (2014)
dc.subjectBreast cancer
dc.subjectChemotherapy
dc.subjectGenetic variation
dc.subjectPrognosis
dc.title2q36.3 is associated with prognosis for oestrogen receptor-negative breast cancer patients treated with chemotherapy
dc.typeinfo:eu-repo/semantics/article
dc.typehttp://purl.org/coar/version/c_ab4af688f83e57aa
dc.typeArtículo de revista


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