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Schizophrenia-like endurable behavioral and neuroadaptive changes induced by ketamine administration involve Angiotensin II AT1 receptor

dc.creatorOcchieppo, Victoria Belén
dc.creatorBasmadjian, Osvaldo Martín
dc.creatorMarchese, Natalia Andrea
dc.creatorJaime, Andrea
dc.creatorPérez, Mariela Fernanda
dc.creatorBaiardi, Gustavo Carlos
dc.creatorBregonzio, Claudia
dc.date2022-05-03
dc.date.accessioned2022-11-01T19:35:19Z
dc.date.available2022-11-01T19:35:19Z
dc.identifierhttp://pa.bibdigital.ucc.edu.ar/3294/1/A_Occhieppo_Basmadjian_Marchese.pdf
dc.identifier.urihttp://test.repositoriodigital.com:8080/handle/123456789/43834
dc.descriptionSchizophrenia is a chronic disease affecting 1% worldwide population, of which 30% are refractory to the available treatments: thus, searching for new pharmacological targets is imperative. The acute and repeated ketamine administration are validated preclinical models that recreate the behavioral and neurochemical features of this pathology, including the parvalbumin-expressing interneurons dysfunction. Angiotensin II, through AT1 receptors (AT1-R), modulates the dopaminergic and GABAergic neurotransmission. We evaluated the AT1-R role in the long-term neuronal activation and behavioral alterations induced by repeated ketamine administration. Adult male Wistar rats received AT1-R antagonist candesartan/vehicle (days 1–10) and ketamine/saline (days 6–10). After 14 days of drug-free, neuronal activation and behavioral analysis were performed. Locomotor activity, social interaction and novel object recognition tests were assessed at basal conditions or after ketamine challenge. Immunostaining for c-Fos, GAD67 and parvalbumin were assessed after ketamine challenge in cingulate, insular, piriform, perirhinal, and entorhinal cortices, striatum, and hippocampus. Additionally, to evaluate the AT1-R involvement in acute ketamine psychotomimetic effects, the same behavioral tests were performed after 6 days of daily-candesartan and a single-ketamine administration. We found that ketamine-induced long-lasting schizophrenia-like behavioral alterations, and regional-dependent neuronal activation changes, involving the GABAergic neurotransmission system and the parvalbumin-expressing interneurons, were AT1-R-dependent. The AT1-R were not involved in the acute ketamine psychotomimetic effects. These results add new evidence to the wide spectrum of action of ketamine and strengthen the AT1-R involvement in endurable alterations induced by psychostimulants administration, previously proposed by our group, as well as their preponderant role in the development of psychiatric pathologies.
dc.descriptionFil: Occhieppo, Victoria Belén. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacología. Instituto de Farmacología Experimental Córdoba (IFEC-CONICET); Argentina
dc.descriptionFil: Basmadjian, Osvaldo Martín. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacología. Instituto de Farmacología Experimental Córdoba (IFEC-CONICET); Argentina
dc.descriptionFil: Marchese, Natalia Andrea. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. CONICET. Centro de Investigaciones en Química Biológica de Córdoba (CIQUIBIC); Argentina
dc.descriptionFil: Marchese, Natalia Andrea. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Biológica “Ranwel Caputto"; Argentina
dc.descriptionFil: Jaime, Andrea. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacología. Instituto de Farmacología Experimental Córdoba (IFEC-CONICET); Argentina
dc.descriptionFil: Pérez, Mariela Fernanda. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacología. Instituto de Farmacología Experimental Córdoba (IFEC-CONICET); Argentina
dc.descriptionFil: Baiardi, Gustavo. Universidad Católica de Córdoba. Facultad de Ciencias Químicas; Argentina
dc.descriptionFil: Bregonzio, Claudia. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacología. Instituto de Farmacología Experimental Córdoba (IFEC-CONICET); Argentina
dc.descriptionFil: Baiardi, Gustavo. Universidad Nacional de Córdoba. Laboratorio de Neurofarmacología (IIBYT-CONICET); Argentina
dc.formatapplication/pdf
dc.languagespa
dc.relationhttp://pa.bibdigital.ucc.edu.ar/3294/
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.bbr.2022.113809
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.sourceOcchieppo, Victoria Belén, Basmadjian, Osvaldo Martín, Marchese, Natalia Andrea, Jaime, Andrea, Pérez, Mariela Fernanda, Baiardi, Gustavo Carlos ORCID: https://orcid.org/0000-0003-4329-4398 <https://orcid.org/0000-0003-4329-4398> and Bregonzio, Claudia (2022) Schizophrenia-like endurable behavioral and neuroadaptive changes induced by ketamine administration involve Angiotensin II AT1 receptor. Behavioural Brain Research, 425. ISSN 0166-4328
dc.subjectQD Química
dc.subjectR Medicina (General)
dc.titleSchizophrenia-like endurable behavioral and neuroadaptive changes induced by ketamine administration involve Angiotensin II AT1 receptor
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo


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