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Genome-wide identification of MITE-derived microRNAs and their targets in bread wheat

dc.creatorCrescente, Juan M.
dc.creatorZavallo, Diego
dc.creatordel Vas, Mariana
dc.creatorAsurmendi, Sebastián
dc.creatorHelguera, Marcelo
dc.creatorFernández, Elmer Andrés
dc.creatorVanzetti, Leonardo S.
dc.date2022-12
dc.date.accessioned2022-11-01T19:35:21Z
dc.date.available2022-11-01T19:35:21Z
dc.identifierhttp://pa.bibdigital.ucc.edu.ar/3302/1/A_Crescente_del%20Vas_Asurmendi.pdf
dc.identifier.urihttp://test.repositoriodigital.com:8080/handle/123456789/43842
dc.descriptionBackground: Plant miRNAs are a class of small non-coding RNAs that can repress gene expression at the post-transcriptional level by targeting RNA degradation or promoting translational repression. There is increasing evidence that some miRNAs can derive from a group of non-autonomous class II transposable elements called Miniature Inverted-repeat Transposable Elements (MITEs). Results: We used public small RNA and degradome libraries from Triticum aestivum to screen for microRNAs production and predict their cleavage target sites. In parallel, we also created a comprehensive wheat MITE database by identifying novel elements and compiling known ones. When comparing both data sets, we found high homology between MITEs and 14% of all the miRNAs production sites detected. Furthermore, we show that MITE-derived miRNAs have preference for targeting degradation sites with MITE insertions in the 3’ UTR regions of the transcripts. Conclusions: Our results revealed that MITE-derived miRNAs can underlay the origin of some miRNAs and potentially shape a regulatory gene network. Since MITEs are found in millions of insertions in the wheat genome and are closely linked to genic regions, this kind of regulatory network could have a significant impact on the post-transcriptional control of gene expression.
dc.descriptionFil: Crescente, Juan M. CONICET; Argentina
dc.descriptionFil: Zavallo, Diego. CONICET. INTA. Instituto de Agrobiotecnología y Biología Molecular (IABIMO), CICVyA; Argentina
dc.descriptionFil: del Vas, Mariana. CONICET. INTA. Instituto de Agrobiotecnología y Biología Molecular (IABIMO), CICVyA; Argentina
dc.descriptionFil: Asurmendi, Sebastián. CONICET. INTA. Instituto de Agrobiotecnología y Biología Molecular (IABIMO), CICVyA; Argentina
dc.descriptionFil: Helguera, Marcelo. EEA INTA; Argentina
dc.descriptionFil: Fernandez, Elmer. Universidad Católica de Córdoba. Centro de Investigación y Desarrollo en Inmunología y Enfermedades Infecciosas (CIDIE-CONICET); Argentina
dc.descriptionFil: Fernandez, Elmer. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina
dc.descriptionFil: Vanzetti, Leonardo S. CONICET; Argentina
dc.descriptionFil: Vanzetti, Leonardo S. EEA INTA; Argentina
dc.formatapplication/pdf
dc.languagespa
dc.publisherBioMed Central Ltd
dc.relationhttp://pa.bibdigital.ucc.edu.ar/3302/
dc.relationhttps://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-022-08364-4
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/10.1186/s12864-022-08364-4
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.sourceCrescente, Juan M., Zavallo, Diego ORCID: https://orcid.org/0000-0002-9021-2175 <https://orcid.org/0000-0002-9021-2175>, del Vas, Mariana ORCID: https://orcid.org/0000-0002-8365-8582 <https://orcid.org/0000-0002-8365-8582>, Asurmendi, Sebastián ORCID: https://orcid.org/0000-0001-9516-5948 <https://orcid.org/0000-0001-9516-5948>, Helguera, Marcelo ORCID: https://orcid.org/0000-0003-4401-8731 <https://orcid.org/0000-0003-4401-8731>, Fernández, Elmer Andrés and Vanzetti, Leonardo S. ORCID: https://orcid.org/0000-0002-7688-5648 <https://orcid.org/0000-0002-7688-5648> (2022) Genome-wide identification of MITE-derived microRNAs and their targets in bread wheat. BMC Genomics, 23 (1). ISSN 1471-2164
dc.subjectQ Ciencia (General)
dc.subjectQK Botánica
dc.titleGenome-wide identification of MITE-derived microRNAs and their targets in bread wheat
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo


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