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Biomarkers of bone and mineral disorders (Fgf-23, fetuin-a) and vascular calcification scores as predictive tools for cardiovascular death in dialysis patients, at 10 years of follow-up[Biomarcadores del metabolismo mineral óseo (Fgf-23, fetuína-a) y calcificaciones vascu-lares como herramientas predictivas de muerte cardiovascular de pacientes en diálisis, a 10 años de seguimiento.]

dc.creatorFernández, Pehuén
dc.creatorDouthat, Walter
dc.creatorCastellano, Mauro
dc.creatorCardozo, Gabriela
dc.creatorGaray, Gabriela
dc.creatorDe Arteaga, Javier
dc.creatorChiurchiu, Carlos
dc.creatorDe La Fuente, Jorge
dc.date2021
dc.date.accessioned2022-11-01T19:35:26Z
dc.date.available2022-11-01T19:35:26Z
dc.identifierhttp://pa.bibdigital.ucc.edu.ar/3327/1/A_Fernandez_Douthat_Castellano.pdf
dc.identifier.urihttp://test.repositoriodigital.com:8080/handle/123456789/43867
dc.descriptionCardiovascular disorders represent the leading cause of death in dialysis patients. Alterations of bone and mineral metabolism (BMM) and vascular calcifications play a fundamental role in it. The objective of this study was to evaluate the predictive role on cardiovascular mortality of the measurement of biomarkers of BMM and vascular calcifications. A prospective cohort study was performed. All prevalent patients on chronic dialysis in September 2009 at our institution, who completed the total of the complementary stud-ies, were studied. BMM biomarkers were measured (FGF 23, fetuin A, PTH, calcium and phosphorus) and the vascular calcifications were evaluated using the Kauppila and Adragao scores. Follow-up was carried out until 1/1/2019, death or transplant. Of the 30 patients included, 7 (23.3%) died due to cardiovascular causes. The follow-up time was 44.1 ± 30.4 (range = 1.4-112) months. The Adragao score was the only predictive variable of long-term cardiovascular mortality (area under the curve = 0.82; 95% CI 0.64-0.94; p < 0.001). The best cut-off point was 5 (sensitivity = 85.7%; specificity = 78.3%). It was also an independent risk factor for cardiovascular mortality adjusted for age, diabetes mellitus, coronary heart disease, aortic calcifications, time spent on dialysis and follow-up time (adjusted OR = 1.77; 95% CI = 1.06-2.96; p = 0.028). The vascular calcifications quantified from the Adragao score were the only independent predictor of long-term cardiovascular mortality. This score represents a simple, useful and superior tool to the biomarkers of BMM.
dc.descriptionFil: Fernández, Pehuén. Hospital Privado Universitario de Córdoba. Servicio de Nefrología; Argentina
dc.descriptionFil: Fernández, Pehuén. Universidad Católica de Córdoba; Argentina
dc.descriptionFil: Fernández, Pehuén. Instituto Universitario de Ciencias Biomédicas de Córdoba (IUCBC); Argentina
dc.descriptionFil: Douthat, Walter. Hospital Privado Universitario de Córdoba. Servicio de Nefrología; Argentina
dc.descriptionFil: Douthat, Walter. Universidad Católica de Córdoba; Argentina
dc.descriptionFil: Douthat, Walter. Instituto Universitario de Ciencias Biomédicas de Córdoba (IUCBC); Argentina
dc.descriptionFil: Castellano, Mauro. Hospital Privado Universitario de Córdoba. Servicio de Nefrología; Argentina
dc.descriptionFil: Castellano, Mauro. Universidad Católica de Córdoba; Argentina
dc.descriptionFil: Cardozo, Gabriela. Hospital Privado Universitario de Córdoba. Servicio de Nefrología; Argentina
dc.descriptionFil: Cardozo, Gabriela. Universidad Católica de Córdoba; Argentina
dc.descriptionFil: Garay, Gabriela. Hospital Privado Universitario de Córdoba. Laboratorio de Química Clínica; Argentina
dc.descriptionFil: DE ARTEAGA, Javier. Hospital Privado Universitario de Córdoba. Servicio de Nefrología; Argentina
dc.descriptionFil: DE ARTEAGA, Javier. Universidad Católica de Córdoba; Argentina
dc.descriptionFil: Chiurchiu, Carlos. Hospital Privado Universitario de Córdoba. Servicio de Nefrología; Argentina
dc.descriptionFil: Chiurchiu, Carlos. Universidad Católica de Córdoba; Argentina
dc.descriptionFil: DE LA FUENTE, Jorge. Hospital Privado Universitario de Córdoba. Servicio de Nefrología; Argentina
dc.descriptionFil: DE LA FUENTE, Jorge. Universidad Católica de Córdoba; Argentina
dc.descriptionFil: DE LA FUENTE, Jorge. Instituto Universitario de Ciencias Biomédicas de Córdoba (IUCBC); Argentina
dc.formatapplication/pdf
dc.languagespa
dc.publisherInstituto de Investigaciones Medicas
dc.relationhttp://pa.bibdigital.ucc.edu.ar/3327/
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.sourceFernández, Pehuén, Douthat, Walter, Castellano, Mauro, Cardozo, Gabriela, Garay, Gabriela, De Arteaga, Javier, Chiurchiu, Carlos and De La Fuente, Jorge (2021) Biomarkers of bone and mineral disorders (Fgf-23, fetuin-a) and vascular calcification scores as predictive tools for cardiovascular death in dialysis patients, at 10 years of follow-up[Biomarcadores del metabolismo mineral óseo (Fgf-23, fetuína-a) y calcificaciones vascu-lares como herramientas predictivas de muerte cardiovascular de pacientes en diálisis, a 10 años de seguimiento.]. Medicina (Argentina), 82 (2). pp. 191-197. ISSN 0025-7680
dc.subjectR Medicina (General)
dc.titleBiomarkers of bone and mineral disorders (Fgf-23, fetuin-a) and vascular calcification scores as predictive tools for cardiovascular death in dialysis patients, at 10 years of follow-up[Biomarcadores del metabolismo mineral óseo (Fgf-23, fetuína-a) y calcificaciones vascu-lares como herramientas predictivas de muerte cardiovascular de pacientes en diálisis, a 10 años de seguimiento.]
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo


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