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Detection of the risk of adenocarcinoma in Barrett's esophagus by means of tumor markers (p53 and ki67)

dc.creatorTrakal, Esteban
dc.creatorGuidi, Andrés Emilio
dc.creatorButti, Abel Luis L.
dc.creatorTrakal, Juan José
dc.creatorSambuelli, Rubén Horacio
dc.creatorZárate, Fabián Eduardo
dc.date2010-09-30
dc.date.accessioned2022-11-01T19:35:51Z
dc.date.available2022-11-01T19:35:51Z
dc.identifierhttp://pa.bibdigital.ucc.edu.ar/3444/1/A_Trakal_Guidi_Butti_Trakal_Sambuelli_Zarate.pdf
dc.identifier.urihttp://test.repositoriodigital.com:8080/handle/123456789/43984
dc.descriptionThe rising incidence of adenocarcinoma in Barrett's esophagus has intensified the research into methods of early recognition of cancer risk, detecting cytological and architectural changes (dysplasia) or using biomarkers as predictive tests. The aim of this paper is to evaluate the involvement of two tumor markers: p53 (tumor suppressor gene) and Ki67 (proliferation marker), by means of immunohistochemical analysis with monoclonal antibodies designed for the specific localization of p53 and Ki67 antigens, in esophageal biopsies with columnar metaplasia of patients with and without dysplasia and adenocarcinoma, and to anticipate which ones are liable to suffer it in the future. Both markers were positive in all intestinal metaplasia patients with high-grade dysplasia and adenocarcinoma, and even in some cases with low grade or without dysplasia. In contrast, in those who have gastric metaplasia, tumor markers were negative. Expression of biomarkers next to dysplasia reduces interobserver variation. Patients with these abnormalities have to be included into a surveillance protocol.
dc.descriptionFil: Trakal, Esteban. Universidad Católica de Córdoba. Facultad de Ciencias de la Salud; Argentina
dc.descriptionFil: Guidi, Andrés Emilio. Universidad Católica de Córdoba. Facultad de Ciencias de la Salud; Argentina
dc.descriptionFil: Butti, Abel Luis L. Universidad Católica de Córdoba. Facultad de Ciencias de la Salud; Argentina
dc.descriptionFil: Trakal, Juan José. Universidad Católica de Córdoba. Facultad de Ciencias de la Salud; Argentina
dc.descriptionFil: Sambuelli, Rubén Horacio. Universidad Católica de Córdoba. Facultad de Ciencias de la Salud; Argentina
dc.descriptionFil: Zárate, Fabián Eduardo. Universidad Católica de Córdoba. Facultad de Ciencias de la Salud; Argentina
dc.formatapplication/pdf
dc.languagespa
dc.publisherSociedad Argentina de Gastroenterología
dc.relationhttp://pa.bibdigital.ucc.edu.ar/3444/
dc.relationhttps://www.redalyc.org/articulo.oa?id=199314783006
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.sourceTrakal, Esteban ORCID: https://orcid.org/0000-0001-9786-6449 <https://orcid.org/0000-0001-9786-6449>, Guidi, Andrés Emilio, Butti, Abel Luis L., Trakal, Juan José ORCID: https://orcid.org/0000-0003-4892-7449 <https://orcid.org/0000-0003-4892-7449>, Sambuelli, Rubén Horacio and Zárate, Fabián Eduardo (2010) Detection of the risk of adenocarcinoma in Barrett's esophagus by means of tumor markers (p53 and ki67). Acta Gastroenterológica Latinoamericana, 40 (3). pp. 211-215. ISSN 0300-9033
dc.subjectR Medicina (General)
dc.titleDetection of the risk of adenocarcinoma in Barrett's esophagus by means of tumor markers (p53 and ki67)
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/acceptedVersion


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